As a product moves from the lab to the market, Tech Futures can assist with developing a commercially viable production process for microbial fermentation based procedures. Services include:
- Scale-up from shaker flask to 10,000-litre
- Optimization of a process using a planned set of parameter variations in multiple computer monitored bioreactors
- On-going production services
Products produced at Tech Futures have had end market application in the segments of:
- Veterinary vaccines
- Aquaculture vaccines
- Pharmaceutical intermediates
- Diagnostics
- Recombinant proteins
- Agricultural products
- Exocellular and intracellular polymers
- Advanced biomaterials
- Specialty chemicals, including enzymes and flavor compounds
Staff are experienced with more than 50 different species of microorganisms and can develop procedures for numerous different organisms and expression systems, both wild type and recombinant, including:
- Bacteria - E.Coli, Streptomyces
- Yeast - Pichia, Saccharomyces
- Algae
- Fungi
- High cell density (fed batch fermentations)
Quality assurance and quality control
A quality program is available to support your process development or to meet your analytical needs.
Technology transfer
NuRx Services can provide clients with manufacturing and technology transfer to regulated manufacturing facilities by access to a network of cGMP alliances.
Microbial fermentation equipment
Numerous equipment options exist for development and scale-up of production processes:
- Fermentors from 20L to 15,000L, with capability for
- oxygen enrichment (most fermenters)
- real-time data acquisition of standard parameters including off-gasses by mass spectrometry
- Centrifuges
- Tubular bowl (7.5 kg bowl capacity)
- Disc stack (up to 10,000 L/hr flow operating volume)
- Cell Disruption Equipment
- Dynomill (5 L volume)
- High Pressure Homogenizer
- Filtration equipment
- Microfiltration skids
- Ultrafiltration skids
- Drying Equipment
Contact Group