Chemical Synthesis - Carbohydrates and other Organic Compounds

Organic synthesis of pharmaceutical and natural health products

Dedicated contracts have involved the synthesis of over 500 new monosaccharides, oligosaccharides or glycoconjugates. Synthetic strategies involve combinatorial chemistry or the rational design approach. Over the years, Tech Futures has made a wide range of products including:

  • Pure carbohydrates, carbohydrate analogs, hetero-atom carbohydrates and carbohybrids
  • Glycoproteins and lipids
  • Aromatic and heterocyclic glycosides
  • Glycomimetics
  • Nucleosides / nucleotides


Examples of some custom synthesis molecules:

  • LpxC substrates, UDP-3-O-((R)-3-hydroxydecanoyl)-GlcNAc, and UDP-3-O-((R)-3-hydroxymyristoyl)-GlcNAc
  • UDP-N-Acetylmuramic acid
  • 2-Amino-2-deoxyglucosyl phosphatidyl-myo-inositol (GlcN-PI)


To take advantage of custom synthesis service, and to assist Tech Futures in better serving your needs, please advise staff of the exact structure and the quantity you require. All enquiries are welcome from customers seeking products not currently listed below.

Monosaccharides
Disaccharides 
Trisaccharides 
Tetrasaccharides


Process scale-up from milligram to multi kilogram quantities
If a product is chemical or biochemically based, Tech Futures can support process development.

  • Process optimization by reducing the number of steps and time involved in a process, while eliminating chromatography steps.
  • Optimization while achieving and maintaining high levels of purity throughout the process.
  • Fume hoods ranging in size from bench-top to walk-in
  • Reactors and rotary evaporators from bench-top to 200L scale
  • Automated fraction collectors


Isolation, extraction and purification
Whether a client needs a substance isolated, or extracted and purified, Tech Futures can meet these needs and generate the accompanying intellectual assets. Let Tech Futures help you develop or improve your process for organic compounds, bioactive natural health product ingredients.


Quality assurance and quality control
A full quality program (QA/QC) is available to support client process development, or to meet analytical needs.


Biosynthesis
Tech Futures has a strong capability in the enzyme-catalyzed synthesis of custom lipids, as well as other permutations and combinations with proteins and carbohydrates. Biosynthesis assumes greater importance where the target compound is to be labeled 'natural', as in the case of functional foods and natural health products.

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